On 8 May 2026, the US National Nuclear Security Administration announced that it removed all enriched uranium from Venezuela.

According to the NNSA report, the removal of the material was first discussed during the visit of DOE Secretary Wright to Venezuela in February 2026. The operation involved NNSA's Office of Defense Nuclear Nonproliferation (DNN), US Department of State personnel in Washington and Caracas, and experts from the United Kingdom, the Venezuelan Ministry of Science and Technology, and the International Atomic Energy Agency (IAEA). The material was transferred to the Savannah River Site in the United States.

The removed material is 13.5 kg of uranium "enriched to just above 20%" contained in spent fuel of the RV-1 research reactor at the Venezuelan Institute for Scientific Research (IVIC). The reactor was shut down in 1991.

According to the information released by the US Global Threat Reduction Initiative (GTRI) program in 2015, the United States removed 54 spent fuel assemblies from Venezuela in October 1998 and 2 spent fuel assemblies in November 1999.