The National Nuclear Security Administration and the South Africa company NTP completed conversion of medical isotope production in South Africa to low enriched uranium. According to NNSA< "NTP is the first major producer of Mo-99 to convert its production from HEU to LEU."

The reactor that is used to produce medical isotopes, Safari-1, was converted to LEU in 2008. Spent HEU fuel was removed to the United States in 2011.