On 21 October 2025, the US Department of Energy issued a Request for Applications DE-FOA-0003594 as part of "a program for making surplus plutonium materials available to industry for advanced nuclear technologies."

The program was established by the May 2025 executive order that also terminated the previously selected disposition route, the dilute and dispose program. That program was authorized in 2016 and sent the first material to WIPP in 2022. It should be noted that the DoE does not exclude the possibility of returning some of the material allocated to the current program to the dilute and dispose route.

The total amount of plutonium that is offered to industry is 19.7 metric tons (MT). Of this, 15.3 MT is in oxide form and 4.4 MT is in the metal form. About 7.1 MT of this is weapon-grade plutonium (about 1 MT is in metal form). The full breakdown by categories is in the table below. An earlier report by Politico suggested that the DoE is prepared to make available up to 25 MT of plutonium.

According to ANS, there are at least four companies that expressed interest in using plutonium: Curio, Lightbridge, Newcleo, and Oklo.