The United States announced that "there is now enough worldwide supply of the medical isotope molybdenum-99 (Mo-99) made without using highly enriched uranium (HEU) to meet the needs of patients in the United States."

According to the DoE statement, this certification will trigger the ban on export of US HEU for medical isotope production. The ban was supposed to enter into force in January 2020, but was postponed for two years since at the time the United States could not obtain all Mo-99 from HEU-free sources. Now the ban is expected to be enforced. The most recent HEU export license for medical isotope production was issued in April 2020.

In addition to HEU export for medical isotope production, the United States also provides HEU for some research reactors. The most recent license application of this kind was submitted in September 2020.